Real-world outcomes in patients with metastatic renal cell carcinoma according to risk factors: the STAR-TOR registry

Strauss A, Schmid M, Rink M, et al.
Future Oncol. 2021 Mar 16.
DOI: 10.2217/fon-2020-1020

Abstract

Aim

Examine outcomes in sunitinib-treated patients by International Metastatic RCC Database Consortium (IMDC) or Memorial Sloan-Kettering Cancer Center (MSKCC) risk factors

Patients & methods

Patients enrolled in STAR-TOR registry (n = 327). End points included overall survival, progression-free survival and objective response rate.

Results

Overall survival was similar for IMDC 0 versus 1 (p = 0.238) or 2 versus ≥3 (p = 0.156), but different for MSKCC (0 vs 1, p = 0.037; 2 vs ≥3, p = 0.001). Progression-free survival was similar for IMDC 2 versus 3 (p = 0.306), but different for MSKCC (p = 0.009). Objective response rate was different for IMDC 1 (41.9%) and 2 (29.5%) and similar for MSKCC 1 (34.4%) and 2 (31.0%). Conclusion: Outcome data varied according to IMDC or MSKCC. MSKCC model accurately stratify patients into risk groups. Clinical trial registration: NCT00700258 (ClinicalTrials.gov).

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