Combination Therapy as First-Line Treatment in Metastatic Renal-Cell Carcinoma

Escudier B.
N Engl J Med. 2019 Feb 16.
DOI: 10.1056/NEJMe1900887

This article has no abstract; the first 100 words appear below.

The treatment of metastatic renal-cell carcinoma has been revolutionized twice in the past 12 years by data showing that vascular endothelial growth factor (VEGF) inhibition can induce tumor shrinkage and increase progression-free survival and that immune checkpoint inhibitors can induce durable responses and increase overall survival among patients with this form of cancer. Guidelines for the treatment of metastatic renal-cell carcinoma have changed dramatically to recommend agents that target these two major pathways. In 2007, a trial showed that sunitinib, a tyrosine kinase inhibitor with potent VEGF inhibition, was superior to interferon alfa, and sunitinib became a new standard of…

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